Predictive Value of Using Endothelial Activation and Stress Index Scoring System for Short-term Prognosis in Sepsis Patients
10.3969/j.issn.1671-7414.2025.01.033
- VernacularTitle:脓毒症患者应用内皮激活和应激指数评分系统对短期预后的预测价值研究
- Author:
Shiyue ZHANG
1
;
Hongshuan LIU
;
Chunlai LIU
;
Xing XU
Author Information
1. 北京市通州区中西医结合医院,北京 101100
- Publication Type:Journal Article
- Keywords:
endothelial activation and stress index;
sepsis
- From:
Journal of Modern Laboratory Medicine
2025;40(1):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between of endothelial activation and stress index (EASIX) and the course and survival ending of sepsis. Methods A retrospective analysis of 197 patients meeting the definition of sepsis 3.0 were admitted to the Tongzhou Campus,Dongzhimeng Hospital of Beijing University of Chinese Medicine from March 2019 to March 2023,and grouped according to the course of disease and prognosis. The SOFA score and APACHE Ⅱ score were used to assess the severity of sepsis. The EASIX index consists of lactate dehydrogenase,creatinine,and platelets. Multivariate COX regression model analysis of factors affecting poor prognosis in sepsis. The receiver operator characteristic (ROC ) curve was drawn to investigate the predictive value of EASIX,SOFA and APACHE Ⅱ scores for the course and 30-day mortality in patients with sepsis. Patient subgroup analysis was performed according to the best cut-off value,and Kaplan-Meier survival curves were drawn. Results Compared with the sepsis group,the EASIX (2.55±0.54 vs 2.30±0.49),APACHE Ⅱ (16.47±4.10 vs 11.81±4.89),SOFA(8.66±3.00 vs 5.48±3.92) scores of the septic shock group were significantly in creased,and EASIX also increased significantly with the progression of the disease,with statistically significant differences(t=-3.293,-7.255,-6.431,all P<0.001). The 30-day mortality rates in the sepsis and septic shock groups were 11.96％ and 29.52％,respectively. EASIX was positively correlated with SOFA scores and APACHE Ⅱ scores (r=0.662,0.425,all P<0.05),and increased with the progression of the disease course(t=3.293,P=0.001). Multivariate COX regression analysis showed that elevated EASIX was an independent risk factor for 30-day death in septic shock[OR(95％CI):1.282(1.135～1.449),P=0.001]. The ROC curve analysis showed that the predictive performance of EASIX for 30-day mortality in septic patients compared with APACHE Ⅱ and SOFA scoring,with no statistically significant difference (Z=1.208,0.538,P=0.227,0.591). The Kaplan-Meier survival curve analysis showed that the 30-day mortality of sepsis patients in the EASIX>2.43 group was significantly higher than that in the EASIX≤ 2.43 group (Log-Rank x2=18.76,P<0.001). Conclusion EASIX is a potential biomarker for predicting poor short-term prognosis in sepsis.
