Progress in studies on the action and mechanism of Lactobacillus reuteri in lowering cholesterol
10.3969/j.issn.1005-4847.2025.01.011
- VernacularTitle:罗伊氏乳杆菌降胆固醇的作用与机制研究进展
- Author:
Haojie AN
1
;
Jiangmei GAO
;
Xiuling ZHONG
;
Qing YAN
;
Cheng LONG
;
Junhua RAO
Author Information
1. 广东省科学院动物研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 510260;华南师范大学生命科学学院,广州 510631
- Publication Type:Journal Article
- Keywords:
probiotics;
Lactobacillus reuteri;
cholesterol-lowering;
action and mechanisms
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(1):108-116
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases that develop from hypercholesterolemia-induced atherosclerosis have emerged as a significant threat to human health.Recently,probiotics exhibiting cholesterol-lowering properties have emerged as a prominent area of research.Numerous studies have demonstrated that Lactobacillus reuteri can effectively reduce endogenous cholesterol synthesis,regulate cholesterol transport,and promote cholesterol degradation by modulating the expression of key genes,such as sterol-regulatory element binding protein 2,3-hydroxy-3-methyl-glutaryl coenzyme A reductase,and cholesterol 7 alpha-hydroxylase,in both the liver and intestinal epithelial cells of the host.This leads to a notable decrease in total cholesterol and low-density lipoprotein cholesterol levels in the host serum.The present paper offers a comprehensive overview of the underlying mechanisms responsible for the cholesterol-lowering effects exerted by L.reuteri,aiming to provide valuable insights into the treatment of hypercholesterolemia and the development of probiotics with cholesterol-lowering properties.
