Correlation between carotid artery lesions and coronary artery stenosis in patients with essential hypertension
- VernacularTitle:原发性高血压患者颈动脉病变与冠状动脉狭窄的相关性研究
- Author:
Junshi ZHANG
1
;
Xiaoping YANG
Author Information
- Publication Type:Journal Article
- Keywords: essential hypertension; carotid artery lesion; coronary artery stenosis
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(1):138-143
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the value of carotid ultrasonographic lesion indices in predicting coronary artery stenosis in patients with essential hypertension,and to analyze their correlation with the degree of coronary artery stenosis.Methods A total of 4 691 patients diagnosed with essential hypertension who visited our cardiac center between January 2020 and September 2023 were included in this study.All the patients underwent carotid ultrasound exam and coronary angiography.Their baseline clinical data were collected,and the severity of coronary artery stenosis was quantified using the Gensini score.Carotid ultrasound parameters,including resistance index(RI),pulsatility index(PI),intima-media thickness(IMT),intimal thickening,plaque formation and luminal stenosis,were evaluated in detail.To control for potential confounders,six multivariate Logistic regression models were constructed to analyze the stratified data on carotid artery lesions.Results Pearson correlation analysis revealed significant positive correlations of PI,RI and IMT with the Gensini score of coronary artery stenosis in hypertensive patients(left PI:r=0.041,P=0.005;right PI:r=0.035,P=0.017;left RI:r=0.119,P＜0.001;right RI:r=0.032,P=0.027;IMT:r=0.043,P=0.003).Multivariate Logistic regression analysis indicated that carotid plaque formation and stenosis were significantly associated with an increased risk of coronary artery disease(CAD)in hypertensive patients(P＜0.001),while intimal thickening was associated with a significantly decreased risk of CAD(P=0.009).Model 2 adjusted for sex,age,educational level,smoking history,systolic blood pressure,and other variables,while Model 3 further adjusted for blood parameters,including white blood cell count,creatinine,and lipid profiles.Stratified analysis of carotid artery lesions showed that intimal thickening combined with plaque formation(Model 5)and plaque formation combined with stenosis(Model 6)were significantly associated with an increased risk of CAD(P＜0.001).In contrast,the difference in patients with only intimal thickening(Model 4)was not statistically significant(P=0.127).Conclusion Carotid ultrasound lesion characteristics are strongly associated with the risk of coronary artery stenosis in patients with essential hypertension,and carotid artery lesions can be used as a useful tool to assess the risk of coronary artery disease in hypertensive patients.
