Effect of Liraglutide combined with intravenous thrombolysis on neurological function and prognosis in acute cerebral infarction patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.05.004
- VernacularTitle:利拉鲁肽联合静脉溶栓改善2型糖尿病合并急性脑梗死患者神经功能及预后的研究
- Author:
Rongdao SUN
1
;
Deqin LUO
;
Guoshuai YANG
Author Information
1. 570208 海口市人民医院神经内科
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction;
Liraglutide;
Intravenous thrombolysis;
Neurological function;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
2025;33(5):336-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Liraglutide(Lir)combined with intravenous thrombolysis on neurological function and prognosis in acute cerebral infarction patients with type 2 diabetes mellitus(T2DM).Methods Totally 137 acute cerebral infarction patients with T2DM were randomly divided into Lir group(69 cases)and Ins group(68 cases).The Ins group was treated with insulin aspart combined with insulin glargine,while the Lir group was treated with Lira combined with insulin glargine.The scores of National Institutes of Health stroke scale(NIHSS)and modified Rankin scale(mRS)were compared between the two groups before and 3 months after treatment.Outpatient follow-up of the two groups was performed to record the recurrence of cerebral infarction and the time.Results After treatment,the scores of NIHSS[(6.51±1.91)vs(8.77±2.03)]and mRS[(2.07±0.58)vs(2.44±0.78)]of Lir group were lower than Ins group(P<0.05).The recurrence risk of cerebral infarction in Lir group was lower than that in Ins group(6.5%vs 22.1%,P<0.05).Conclusions The treatment of Lir combined with intravenous thrombolysis can effectively reduce neurological deficits and the recurrence risk in acute cerebral infarction patients with T2DM.
