Potential of mitochondrial transplantation in treatment of sarcopenia
- VernacularTitle:线粒体移植治疗肌少症的潜力
- Author:
Wei LI
1
;
Hongtao YIN
;
Yongchen SUN
;
Weijuan XU
;
Jinling SUN
;
Xiaodong JIN
Author Information
- Publication Type:Journal Article
- Keywords: sarcopenia; mitochondrial dysfunction; mitochondrial quality control; mitochondrial transplantation; limitations
- From: Chinese Journal of Tissue Engineering Research 2025;29(13):2842-2848
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Sarcopenia is a comprehensive condition of aging induced decline in skeletal muscle mass and strength and represents a major health challenge for the elderly.Accumulating evidence suggests that mitochondrial dysfunction plays a key role in the pathogenesis of sarcopenia.OBJECTIVE:To summarize the mechanisms by which dysregulation of mitochondrial quality control leads to sarcopenia and to explore whether mitochondrial transplantation may be a potential target for the treatment of sarcopenia.METHODS:We searched PubMed and CNKI databases for relevant articles published from 2009 to 2023 using the keywords "sarcopenia,mitochondrial dysfunction,mitochondrial quality control,mitochondrial transplantation,limitations."RESULTS AND CONCLUSION:Given the key role of mitochondrial dysfunction in the pathogenesis of sarcopenia,mitochondrial transplantation may serve as a possible strategy for the treatment of sarcopenia by improving mitochondrial bioenergetics and modulating mitochondria related signaling pathways.Although some preclinical and clinical studies have confirmed the potential of mitochondrial transplantation for the treatment of various diseases,there are still some urgent questions regarding the specific details of mitochondrial transfer.
