Mendelian Randomization Study on Immune Cells and Heart Failure
10.11969/j.issn.1673-548X.2025.01.006
- VernacularTitle:免疫细胞与心力衰竭的孟德尔随机化研究
- Author:
Yibo ZHANG
1
;
Jianqi LU
;
Meiling MAO
Author Information
1. 530000 南宁,广西中医药大学
- Publication Type:Journal Article
- Keywords:
Immune cells;
Heart failure;
Mendelian randomization;
Causal relationship
- From:
Journal of Medical Research
2025;54(1):25-30,42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To utilize a comprehensive two-sample Mendelian randomized analysis for determining the causal relation-ship between immune cells and heart failure.Methods Immune cell data were collected from the genome-wide association analysis da-tabase,while the data of heart failure were obtained from the FinnGen database.The inverse variance weighted method,MR-Egger re-gression method,weighted median method,and weighted model method were employed to analyze the causal relationship between immune cells and heart failure.Comprehensive sensitivity analysis was utilized to verify the robustness,heterogeneity,and level pleiotropy of the results.The Stsiger test was applied to determine whether there was a reverse causal relationship between heart failure and immune cells.Results A total of 2557single nucleotide polymorphisms(SNP)were obtained from 731 immune cells.A total of 25 immunophenotypes were identified as having a causal function before the adjustment.After Bonferroni adjustment,only three results retained statistical signifi-cance.The inverse variance weighted analysis showed that there was a significant causal relationship between the absolute lymphocyte count and the increased risk of heart failure(HF)(OR=1.199,95％CI:1.104-1.302,P=1.70 × 10-5).The absolute count of T cells(OR=1.186,95％CI:1.095-1.284,P=2.84×10-5),and the absolute count of plasma-like dendritic cells(OR=1.137,95％CI:1.056-1.224,P=0.0007)were positively correlated with HF.The Stsiger test did not detect a causal relationship between heart failure and immune cells.Conclusion There exists a causal relationship between immune cells and the risk of heart failure.
