Otitis media as initial manifestation of antineutrophil cytoplasmic antibody-associated vasculitis
10.3969/j.issn.1006-7299.2025.03.010
- VernacularTitle:以中耳炎为首发表现的抗中性粒细胞胞浆抗体相关血管炎临床特征
- Author:
Ying LIN
1
;
Yan QIAO
1
;
Runqin YANG
1
;
Zhuo XU
1
;
Dingjun ZHA
1
Author Information
1. 空军军医大学第一附属医院耳鼻咽喉头颈外科(西安 710032)
- Publication Type:Journal Article
- Keywords:
Otitis media;
Antineutrophil cytoplasmic antibody;
Auto-immune diseases
- From:
Journal of Audiology and Speech Pathology
2025;33(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical features and treatment outcomes of otitis media caused by antineu-trophil cytoplasmic antibody ANCA-associated vasculitis[otitis media with AAV(OMAAV)].Methods A total of 19 cases of OMAAV diagnosed between September 2015 to September 2022 were studied.OMAAV was defined using the criteria introduced by Japan Society of Otology.Results Median age of all patients was 61.8 years old,predominantly proteinase 3(PR3)positive(47.3％).Averaged score of vasculitis activity was 6.6.Disease also in-volved lung(84.2％),nose(73.7％)and facial nerve(21.0％).Pathological biopsy was performed in nine pa-tients,and two reports indicated ANCA-related disease.Fourteen affected ears of eight patients showed mixed hear-ing loss.The administration of corticosteroid together with an immunosuppressant significantly improved hearing,from averaged air conduction of 75.1±23.2 dB HL to 50.5±22.1 dB HL after treatment(P＜0.05).Conclusion Otologists shall be aware of OMAAV when handling intractable otitis media in elderly patients if bone conduction hearing gets worse and there are other affected organs.Immunological serum test is an important diagnostic basis.Most patients were misdiagnosed for certain time,and hearing level might not be improved unless early diagnose and proper treatment.
