Study on influencing factors for cerebral small vessel disease in type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.05.007
- VernacularTitle:2型糖尿病合并脑小血管病变影响因素的研究
- Author:
Chenye XIE
1
;
Zhaojie JI
;
Zhen CHEN
;
Liang JIN
;
Zhou MEI
Author Information
1. 230001 安徽医科大学合肥第三临床学院药学部
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Cerebral small vessel disease;
Influence factor
- From:
Chinese Journal of Diabetes
2025;33(5):350-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors forcerebral small vessel disease(CSVD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 160 patients with T2DM admitted to the Department of Endocrinology our hospital were enrolled in this study from January 2024 to March 2024,and divided into simple T2DM group(n=107)and T2DM combined with CSVD(CSVD,n=53)group according to the combination of CSVD.The general information and biochemical indicators were compared between the two groups.Logistic regression analysis was used to analyze the influencing factors for CSVD in patients with T2DM,and ROC curve was used to evaluate the diagnostic efficacy of CSVD markers.Results The CSVD group showed significantly higher values than the T2DM group(P<0.05)in the following parameters:DM duration,serum uric acid,cystatin C(CysC),neutrophils,monocytes,C-RP,monocyte-to-high-density lipoprotein cholesterol ratio(MHR),and PAC-1 levels.Conversely,the CSVD group had significantly lower levels of LDL-C,lymphocytes,and albumin-to-globulin ratio(A/G)compared to the T2DM group(P<0.05).Logistic regression analysis indicated that A/G,CysC,MHR,and DM duration were influencing factors for T2DM complicated with CSVD.Receiver operating characteristic(ROC)curveanalysis demonstrated that the combined prediction model incorporating A/G,CysC,MHR,and DM duration yielded an area under the curve of 0.88,indicating good predictive performance.Conclusions A/G,CysC,MHR,and duration are independent risk factors for CSVD in patients with T2DM.Early identification of these items may facilitate the prevention of CSVD in patients with T2DM.
