The predictive value of the sequential organ failure score combined with Clara cell protein and angiopoietin-2 in ARDS induced by sepsis
10.11958/20242304
- VernacularTitle:序贯器官衰竭评分联合Clara细胞蛋白和血管生成素-2对脓毒症所致ARDS的预测价值
- Author:
Zhuo HU
1
;
Songbo XIE
1
;
Shiwei YOU
1
Author Information
1. 监利市人民医院重症医学科 433300
- Publication Type:Journal Article
- Keywords:
sepsis;
respiratory distress syndrome;
angiopoietin-2;
uteroglobin;
prognosis;
ROC curve
- From:
Tianjin Medical Journal
2025;53(5):519-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of sequential organ failure score(SOFA)combined with serum Clara cell protein 16(CC16)and angipoietin-2(Ang-2)in the prognosis of patients with acute respiratory distress syndrome(ARDS)caused by sepsis.Methods A total of 173 sepsis patients were divided into the concurrent group(n=76)and the non-concurrent group(n=97),based on whether ARDS occurred within 72 h after admission.According to the death situation within 30 days,patients in the concurrent group were divided into the death group(n=35)and the survival group(n=41).Enzyme-linked immunosorbent assay(ELISA)was used to detect serum CC16,Ang-2,C-reactive protein(CRP)and interleukin(IL)-6.The levels of triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and white blood cell count(WBC)were detected by automatic biochemical analyzer and hemocytometer.SOFA scores were performed on patients at admission.The biochemical indexes,SOFA score,CC16 and Ang-2 levels were compared between the two groups,and the poor prognosis of the patients was analyzed.Binary Logistic regression was used for influencing factor analysis.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of related factors in the poor prognosis of patients with sepsis complicated by ARDS.Results The serum levels of CRP,IL-6,CC16,Ang-2 and SOFA scores were higher in the concurrent group than those in the non-concurrent group(P＜0.05).The SOFA score,mechanical ventilation time,CRP,CC16 and Ang-2 were higher in the death group than those in the survival group(P＜0.05).High SOFA score,CC16 and Ang-2 were independent risk factors for poor prognosis in the concurrent group(P＜0.05).The area under the curve(AUC)of SOFA score,serum CC16 and Ang-2 levels in predicting poor prognosis in patients with sepsis complicated with ARDS were 0.806(0.700-0.888),0.801(0.693-0.884),0.845(0.743-0.918)and 0.945(0.867-0.984),respectively.Conclusion SOFA score combined with changes in CC16 and Ang-2 expression levels can be used to comprehensively evaluate prognosis of patients with sepsis complicated with ARDS.
