Effects of quercetin loaded with different nanomaterials on prevention and treatment of brain edema in rats at high altitude
10.19745/j.1003-8868.2025083
- VernacularTitle:不同纳米材料负载槲皮素防治高原大鼠脑水肿的作用研究
- Author:
Qing-yan YAN
1
;
Min DU
;
Hong LUO
;
Mi TANG
Author Information
1. 西部战区总医院肿瘤科,成都 610083
- Publication Type:Journal Article
- Keywords:
quercetin;
high altitude brain edema;
zeolitic imidazolate framework-8;
mesoporous silica;
carbon quantum dots
- From:
Chinese Medical Equipment Journal
2025;46(5):27-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the preventive and therapeutic effects of quercetin(QU)loaded with different nanomate-rials on high altitude cerebral edema(HACE)in rats and their mechanisms.Methods Thirty male SD rats were selected and equally divided into a normoxic group,a HACE group,a HACE+QU group,a HACE+carbon quantum dots(CQDs)-loaded QU(QU@CQDs)group,a HACE+mesoporous silica(MS)-loaded QU(QU@MS)group and a HACE+zeolitic imida-zolate framework-8(ZIF-8)loaded QU(QU@ZIF-8)group.The rats except those in the normoxic group were exposed to a simulated 5 000 m altitude in a low-pressure oxygen chamber,which were orally administered QU at a dose of 5 mg/g body mass 1 h before hypoxic exposure except those in the HACE group.The groups were compared in terms of the effects of the materials on the water content of rat brain tissue,cerebrovascular leakage,hematological changes and NF-κB-related mechanisms.Statistical analysis was performed using SPSS 26.0 software.Results When compared with the rats in the normoxic group,the ones in the HACE group showed significant increases in brain tissue water content,cerebrovascular leakage,leukocytes,erythrocytes,lymphocytes,monocytes,granulocytes,mean erythrocyte volume,hemoglobin,hematocrit,platelets,reactive oxygen species and malondialdehyde and NF-κB protein levels,with obvious oxidative damage and statistically decreased oxidative stress parameters including glutathione peroxidase,glutathione and superoxide dismutase(all P＜0.05).When compared with the HACE+QU@CQDs and HACE+QU@MS groups,the HACE+QU@ZIF-8 group gained advantages with the lowest brain tissue water content,improved cerebrovascular leakage,leukocytes,erythrocytes,lymphocytes,monocytes,granulocytes,mean erythrocyte volume,hematocrit,platelets and hemoglobin,decreased oxidative damagea and oxidative stress,enhanced antioxidant enzyme levels and the statistically lowered NF-κB protein level.Conclusion ZIF-8 loaded QU behaves better than CQDs and MS in reducing inflammation and brain edema formation in HACE rats.[Chinese Medical Equipment Journal,2025,46(5):27-33]
