Clinical analysis of 8 cases of spontaneous cerebrospinal fluid rhinorrhea with aspiration pneumonia
10.3760/cma.j.cn115330-20240223-00102
- VernacularTitle:自发性脑脊液鼻漏引发吸入性肺炎8例临床分析
- Author:
Huikang WANG
1
;
Yang ZHENG
;
Haoran LU
;
Yu ZHANG
Author Information
1. 青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科，烟台 264000
- Publication Type:Journal Article
- Keywords:
Cerebrospinal fluid rhinorrhea;
Aspiration pneumonia;
Postnasal drip;
Risk factor;
Repair of cerebrospinal fluid rhinorrhea
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2024;59(12):1313-1318
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, treatment, and efficacy of spontaneous cerebrospinal fluid rhinorrhea (CFR) combined with aspiration pneumonia.Methods:In this case series study, a total of 8 patients diagnosed with spontaneous CFR combined with aspiration pneumonia were admitted to the Department of Otorhinolaryngology Head and Neck Surgery at Yuhuangding Hospital Affiliated with Qingdao University from March 2020 to March 2022. There were 3 males and 5 females, with ages ranging from 45 to 57 years. Endoscopic repair of CFR was performed for all patients. Retrospective analysis was conducted on the symptoms, chest CT findings, the leak location of CFR, and laboratory virological test results. The healing of the operative cavity and the recovery of pulmonary inflammation were followed up.Results:All the 8 patients had obvious postnasal cerebrospinal fluid drip with different degrees of dry cough, which was aggravated when lying flat and sleeping. Bone defects of CFR were predominantly located in the sphenoid sinus, lamina cribrosa and ethmoid roof. Chest CT scans upon admission showed multiple flocculent ground glass opacities and inflammatory changes in both lungs. Tests for TORCH (TOX, RV, CMV, HSV), EB (Epstein-Barr) virus nucleic acid, nine respiratory pathogens, 2019-nCoV oropharyngeal swab, and serum immunoglobulin(Ig)M/IgG were all negative. Seven patients were cured after endoscopic repair of CFR. CFR occurred again in one patient due to head trauma, and no recurrence was observed for 3 months after reoperation. Postoperative chest CT scans confirmed the resolution of aspiration pneumonia in all 8 patients.Conclusions:Aspiration pneumonia may arise from the aspiration of cerebrospinal fluid in patients with spontaneous CFR. Early diagnosis and timely repair of CFR contribute to the recovery of aspiration pneumonia.
