Research progress of mitophagy in the pathogenesis of sensorineural hearing loss
10.3969/j.issn.1006-7299.2025.03.016
- VernacularTitle:线粒体自噬在感音神经性听力损失发病机制中的研究进展
- Author:
Yingdong ZHOU
1
;
Mengxian ZHANG
;
Qingling WANG
;
Haoran KANG
;
Xiangdong GUO
Author Information
1. 河南中医药大学第一临床医学院(郑州 450046)
- Publication Type:Journal Article
- Keywords:
Sensorineural hearing loss;
Mitophagy;
Oxidative stress
- From:
Journal of Audiology and Speech Pathology
2025;33(3):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy is a selective degradation process of damaged mitochondria in response to mitochondrial toxicity,which plays a crucial role in regulating mitochondrial quality and quantity.Abnormal mitophagy can cause or exacerbate mitochondrial dysfunction,which is closely associated with the pathogenesis of numerous diseases.Given that cochlear hair cells are highly sensitive to energy metabolism,proper regulation of mitophagy is essential for maintaining auditory function.Mitochondrial damage resulting from mitophagy dysfunction involves diverse pathophysiological mechanisms underlying sensorineural hearing loss.This review summarizes the latest progress on mitophagy and its role in the pathogenesis of sensorineural hearing loss,aiming to enhance our understanding of the involvement of mitophagy in auditory function and provide a theoretical basis for future research on targeted therapy for mitochondria.
