Predictive value of serum FGF-21, IGF-1, and SF for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism
10.3760/cma.j.cn431274-20250325-00430
- VernacularTitle:血清FGF-21、IGF-1、SF对妊娠合并甲状腺功能减退患者母婴结局的预测价值
- Author:
An KOU
1
;
Qian JIANG
1
;
Feng SHEN
1
;
Kechun ZHANG
1
Author Information
1. 安康市中心医院检验科，安康 725000
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 21;
Insulin-like growth factor 1;
Ferritin;
Pregnancy;
Hypothyroidism;
Pregnancy outcome
- From:
Journal of Chinese Physician
2025;27(11):1701-1705
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of serum fibroblast growth factor-21 (FGF-21), insulin-like growth factor-1 (IGF-1), and serum ferritin (SF) for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism.Methods:A total of 246 patients with pregnancy complicated by hypothyroidism who underwent prenatal examination at the Ankang Central Hospital from January 2021 to September 2024 were retrospectively selected as the observation group. Meanwhile, 100 healthy pregnant women who received prenatal examination in the hospital during the same period were enrolled as the control group. According to the maternal and infant outcomes, the observation group was divided into the adverse maternal and infant outcome group ( n=55) and the favorable maternal and infant outcome group ( n=191). Baseline data were compared among groups. Pearson correlation analysis was used to evaluate the correlations between FGF-21, IGF-1, SF and thyroid hormone levels. Univariate and multivariate analyses were applied to screen the influencing factors of maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism. Receiver operating characteristic (ROC) curve was drawn to assess the predictive value of FGF-21, IGF-1, and SF for adverse maternal and infant outcomes in these patients. Results:The serum levels of FGF-21 and thyroid-stimulating hormone (TSH) in the observation group were higher than those in the control group (all P<0.05), while the levels of IGF-1, SF, free thyroxine (FT4), and free triiodothyronine (FT3) were lower (all P<0.05). Pearson correlation analysis showed that in patients with pregnancy complicated by hypothyroidism, FGF-21 was positively correlated with TSH and negatively correlated with FT4 and FT3 (all P<0.05); IGF-1 and SF were negatively correlated with TSH and positively correlated with FT4 and FT3 (all P<0.05). Univariate analysis indicated that FGF-21, IGF-1, SF, TSH, and FT4 were related to maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism (all P<0.05). Multivariate logistic regression analysis revealed that FGF-21 was an independent risk factor for adverse maternal and infant outcomes, while IGF-1 and SF were protective factors (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum FGF-21, IGF-1, and SF alone for predicting adverse maternal and infant outcomes were 0.811, 0.738, and 0.837, with sensitivities of 84.1%, 81.3%, and 76.6%, respectively—all lower than the AUC (0.876) and sensitivity (93.5%) of combined prediction, with statistically significant differences (all P<0.05). Conclusions:FGF-21, IGF-1, and SF are independent influencing factors for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism, and have good predictive value for adverse maternal and infant outcomes.
