Study on the TCM drug-symptom patterns in the treatment of idiopathic pulmonary fibrosis based on the " three-stage differentiated management" principle
10.3760/cma.j.cn431274-20241206-01824
- VernacularTitle:基于"三期分治"原则对特发性肺间质纤维化中医治疗的药证规律研究
- Author:
Qian MA
1
;
Xinyue CHEN
;
Caijun WU
;
Jun YAN
;
Wei BI
Author Information
1. 北京中医药大学东直门医院急诊科，北京 100700
- Publication Type:Journal Article
- Keywords:
Idiopathic pulmonary fibrosis;
Micro zhengjia in lung collateral;
Three stages of treatment;
Data mining;
Medication regularity
- From:
Journal of Chinese Physician
2025;27(11):1664-1671
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the therapeutic methods and drug-symptom patterns of Traditional Chinese Medicine (TCM) for idiopathic pulmonary fibrosis (IPF) at different stages under the guidance of the " three-stage differentiated management" principle.Methods:Under the three-stage principle, 133 IPF prescriptions treated by prof. Yan Jun from 2017.2-2023.12 were analyzed. Disease and category information of each eligible case was entered into the " FangNet" platform. Association and cluster analyses were performed for core herbs, key herb pairs, and symptom-drug relationships, aiming to uncover the clinical medication characteristics and rules in the three stages.Results:(1) Early inflammatory stage: phlegm-stasis harassment, incipient but unformed masses, superficial disease location; priority was dispelling wind, dispersing pathogen, clearing lung and resolving phlegm-commonly used: ephedra, stemona, processed pinellia, peucedanum, armeniaca. (2) Mid injury stage: formed phlegm-stasis, struggle of pathogen and healthy Qi, impaired lung collaterals, obstructive phlegm-stasis, excess pathogen with intact healthy Qi; emphasis on expelling pathogen, resolving phlegm, activating blood and dredging collaterals-e.g., angelica, pheretima, bombyx, scorpio. (3) Late fibrotic stage: healthy Qi deficiency with excess pathogen, phlegm-stasis masses entrenched in collaterals; treatment focuses on tonifying lung and dissolving masses, combining dredging and tonifying to regulate Qi and blood-e.g., pinellia, rhodiola, ginseng, gecko.Conclusions:Phlegm-stasis as excess pathogen and dual deficiency of lung-kidney run through all three stages of IPF. The rise and fall of healthy Qi vs pathogen and the degree of mass formation determine stage-specific therapeutic strategies and drug-pattern adjustments.
