Research progress on alternation of the m6A modification-associated epitranscrip-tomes and related function during animal virus infection
10.16303/j.cnki.1005-4545.2025.01.22
- VernacularTitle:动物病毒感染过程中转录组m6A甲基化修饰变化及功能研究进展
- Author:
Xilong YANG
1
;
Xiangqi QIU
1
;
Jiajing TIAN
1
;
Mengjie LI
1
;
Lele GONG
1
;
Lele WANG
1
;
Aijun SUN
1
;
Guoqing ZHUANG
1
Author Information
1. 河南农业大学动物医学院国家动物免疫学国际联合研究中心,河南郑州 450046
- Publication Type:Journal Article
- Keywords:
m6 A methylation modification;
ASFV;
PRRSV;
MDV;
NDV
- From:
Chinese Journal of Veterinary Science
2025;45(1):163-169,174
- CountryChina
- Language:Chinese
-
Abstract:
Diseases caused by animal virus infection seriously restricts the healthy development of animal husbandry.In-depth study of the molecular mechanism of viral replication and pathogenesis will provide theoretical basis for screening vaccine and drug targets.N6-methyladenosine(m6 A)modification occurs extensively in viral and host transcriptomes and affects viral replication and pathogenicity by regulating gene expression,which acts as a novel regulator of gene expression in addition to DNA and protein modifications.Insight into the regulatory molecular mechanism of m6 A modification in virus infection is the research hotspots and frontiers.In recent years,there are re-ports of alternation of the m6 A modification-associated epitranscriptomes and related function a-nalysis during virus infection.Here,we summarize the alternation of the epitranscriptomes induced by African swine fever virus(ASFV),porcine reproductive and respiratory syndrome virus(PRRSV),porcine epidemic diarrhoea virus(PEDV),cestode virus(CSFV),porcine pseudorabies virus(PRV),Marek's disease virus(MDV),Newcastle disease virus(NDV),avian leukaemia virus(ALV)and duck hepatitis A virus(DHAV)infection,and the subsequent effects on viral replica-tion and pathogenicity.We also discuss the potential role and molecular mechanism of m6 A modification in animal virus replication and pathogenesis,which will contributes to the prevention and control for animal disease.
