Research advances on necroptosis in viral infections
10.16303/j.cnki.1005-4545.2025.01.21
- VernacularTitle:坏死性凋亡在病毒性感染中作用机制的研究进展
- Author:
Yiyu LIU
1
;
Jingyi NIU
1
;
Yu DAI
1
;
Chao YE
1
Author Information
1. 西南大学动物医学院,重庆 400715
- Publication Type:Journal Article
- Keywords:
necroptosis;
virus;
viral infection;
molecular mechanism;
inhibitors
- From:
Chinese Journal of Veterinary Science
2025;45(1):153-162
- CountryChina
- Language:Chinese
-
Abstract:
Programmed cell death plays an important role in the growth and development of organ-ism and homeostasis of tissues and organs.Necroptosis,a new mode of programmed cell death,characterized by necrosis in morphology,can cause cell breakdown and release of a significant num-ber of damage-associated molecular patterns,which play an important role in the occurrence and development of diseases.Viral infection is a serious health risk to both humans and domestic ani-mals.Research has confirmed that necroptosis functions as a cell death pathway in viral infections.In this paper,we review the current research advances on necroptosis related to viral infections,e-lucidate the molecular mechanism of mutual regulation between viral infection and necroptosis,and discuss the progress in the application of necroptosis inhibitors,to provide new ideas for the pre-vention and treatment of viral infections.
