Predictive value of non-high-density lipoprotein cholesterol combined with left ventricular ejection fraction for in-stent restenosis in patients with coronary heart disease
10.3760/cma.j.cn431274-20241012-01546
- VernacularTitle:非高密度脂蛋白胆固醇联合左室射血分数对冠心病患者支架内再狭窄的预测价值
- Author:
Lanying HUO
1
;
Cuiling JI
;
Jingzhi SUN
;
Yong CAO
;
Jinguo ZHANG
Author Information
1. 济宁医学院临床医学院，济宁 272013
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Non-high-density lipoprotein cholesterol;
Left ventricular ejection fraction;
In-stent restenosis
- From:
Journal of Chinese Physician
2025;27(11):1633-1637
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of non-high-density lipoprotein cholesterol (non-HDL-C) combined with left ventricular ejection fraction (LVEF) for in-stent restenosis (ISR) in patients with coronary heart disease (CHD).Methods:Clinical data of 476 CHD patients who underwent percutaneous coronary intervention (PCI) at the Affiliated Hospital of Jining Medical University from January 2021 to December 2022 were retrospectively analyzed. All patients underwent postoperative coronary angiography reexamination, and were divided into the ISR group (257 cases) and non-ISR group (219 cases) according to the reexamination results. Baseline data were compared between the two groups. Multivariate logistic regression analysis was used to identify the influencing factors of ISR, and receiver operating characteristic (ROC) curve was applied to analyze the predictive value of non-HDL-C, LVEF, and their combination for ISR.Results:The proportion of complicated hypertension, levels of low-density lipoprotein cholesterol (LDL-C) and non-HDL-C in the ISR group were higher than those in the non-ISR group (all P<0.05), while LVEF and stent diameter were smaller than those in the non-ISR group (all P<0.05). Multivariate logistic regression analysis showed that after adjusting for confounding factors, non-HDL-C and LVEF were independent risk factors for ISR in CHD patients after PCI (all P<0.05). ROC curve analysis indicated that the area under the curve (AUC) of non-HDL-C for predicting ISR in CHD patients was 0.648(95% CI: 0.597-0.698, P<0.05), with a sensitivity of 0.461 and specificity of 0.794; the AUC of LVEF for predicting ISR was 0.628(95% CI: 0.577-0.680, P<0.05), with a sensitivity of 0.452 and specificity of 0.863; the AUC of their combination for predicting ISR was 0.701(95% CI: 0.662-0.781, P<0.05), with a sensitivity of 0.782 and specificity of 0.588. Conclusions:Non-HDL-C, LVEF, and stent diameter are independent risk factors for ISR in CHD patients after PCI. Single detection of non-HDL-C or LVEF has predictive value for ISR, and their combination can improve the predictive efficiency, which has higher clinical application value.
