Research progress on the role and mechanism of fibroblast growth factors in the proliferative phase of wound healing
10.3760/cma.j.cn431274-20250721-00966
- VernacularTitle:成纤维细胞生长因子在创面愈合增殖阶段的作用及机制研究进展
- Author:
Bo CHEN
1
;
Tao CAO
;
Qian XU
;
Wenqiao HE
;
Xiaokun LI
;
Ke TAO
Author Information
1. 温州医科大学药学院，温州 325000
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor;
Wound healing;
Cell proliferation;
Angiogenesis
- From:
Journal of Chinese Physician
2025;27(11):1619-1625
- CountryChina
- Language:Chinese
-
Abstract:
Various growth factors are key molecules in wound healing and exert regulatory effects at all stages of healing. Fibroblast growth factors (FGFs), with their prominent pro-growth activity, play a crucial role in promoting proliferation during the proliferative phase of wound healing. By binding to fibroblast growth factor receptors, FGFs activate downstream signaling pathways to regulate wound inflammation, reduce oxidative stress, promote cell proliferation, angiogenesis, and extracellular matrix remodeling. This facilitates the transition of wounds from the " inflammatory phase" to the " proliferative phase" and enhances proliferative healing. The clinical therapeutic value of FGFs in acute and chronic wounds has been widely confirmed, but their full efficacy is limited by issues such as short half-life and poor delivery efficiency. Research focusing on innovative FGF delivery materials and molecular modification strategies will become a key direction to break through current therapeutic bottlenecks and unlock their greater therapeutic potential.
