Advances in immunological research on hematopoietic stem cell transplantation
10.3969/j.issn.1006-5725.2025.05.004
- VernacularTitle:异基因造血干细胞移植后的免疫相关研究进展
- Author:
Xingchi CHEN
1
;
Xiaoyu ZHU
1
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)血液科、中国科学技术大学生命科学与医学部血液和细胞治疗研究所、血细胞研究及应用安徽省重点实验室(安徽 合肥 230001)
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
immunological mechanisms;
malignant hemato-logical diseases
- From:
The Journal of Practical Medicine
2025;41(5):641-647
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is a therapeutic approach that restores hematopoietic and immune functions in recipients through the infusion of allogeneic hematopoietic stem cells.It has evolved into an effective form of adoptive cellular immunotherapy,offering curative potential for vari-ous diseases,including malignant hematologic disorders,hematopoietic failure syndromes,congenital immunodefi-ciencies,and genetic metabolic disorders.Immunology plays a pivotal role in allo-HSCT,as post-transplant immu-nobiology is uniquely characterized by the potential for immune recognition and attack between donor and host cells.This review elucidates the distinctive features of immune reconstitution following allo-HSCT,examines the immunological underpinnings of graft-versus-host disease(GVHD)and the graft-versus-leukemia(GVL)effect,and evaluates how novel therapeutic strategies modulate these immune responses to improve the management of transplant-related complications and enhance patient outcomes.Additionally,the review addresses the challenges in balancing GVHD and GVL effects and outlines potential directions for future research.
