Emphasizing research on geriatric wounds and improving regenerative repair levels: A multidimensional perspective from microscopic regulation to comprehensive prevention and control
10.3760/cma.j.cn431274-20251106-01374
- VernacularTitle:重视老年创面研究，提升再生修复水平
- Author:
Daitian TANG
1
;
Xianrui WU
;
Chunmeng SHI
;
Ke TAO
;
Jianda ZHOU
Author Information
1. 中南大学湘雅三医院整形外科，长沙 410013
- Publication Type:Journal Article
- Keywords:
Aged;
Wound repair;
Integration of traditional Chinese and western medicine;
Fibroblast growth factor;
Exosomes;
Drug-resistant bacterial infection
- From:
Journal of Chinese Physician
2025;27(11):1601-1603
- CountryChina
- Language:Chinese
-
Abstract:
The global aging intensification has made geriatric wound repair a medical challenge. Diabetic foot and venous ulcers are highly prevalent and difficult to heal in the elderly population, seriously affecting patients′ quality of life and increasing medical burdens. The repair of geriatric wounds is constrained by multiple factors, including weakened regenerative capacity and immune dysfunction. Current research has gradually focused on mechanism analysis and precise intervention. Fibroblast growth factor (FGF) has been confirmed as a key factor in wound repair, and exogenous FGF can activate signaling pathways to promote wound healing. Exosomes have shown an important role in wound regeneration by promoting cell migration and proliferation, thereby accelerating the wound healing process. Geriatric wounds also face the challenge of drug-resistant bacterial infections, so future treatment strategies should combine microecological reconstruction and immune function recovery. Overall, research on geriatric wounds has formed a multidimensional repair framework aimed at activating the regenerative capacity of aging organisms.
