Opportunities and challenges of NK cell therapy
10.3969/j.issn.1006-5725.2025.05.001
- VernacularTitle:自然杀伤细胞疗法的机遇与挑战
- Author:
Yiyang DING
1
;
Xiangyu ZHAO
1
Author Information
1. 北京大学人民医院、北京大学血液病研究所、国家血液系统疾病临床医学研究中心、血液肿瘤细胞和基因治疗北京市重点实验室(北京 100044)
- Publication Type:Journal Article
- Keywords:
natural killer cells;
cell therapy;
chimeric antigen receptor NK cells
- From:
The Journal of Practical Medicine
2025;41(5):621-627
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer(NK)cells are essential components of the innate immune system,characterized by their ability to identify and eliminate abnormal cells through receptors that operate independently of major histo-compatibility complex(MHC)restriction.As a result,NK cells play a critical role in anti-tumor,antiviral,and immune regulatory responses.Chimeric antigen receptor NK cell therapy(CAR-NK)enhances the targeting speci-ficity and functional activity of NK cells,thereby augmenting their cytotoxic potential and opening new avenues for cancer treatment.To date,numerous clinical trials have evaluated NK cell therapy for anti-tumor,antiviral,and autoimmune diseases.This article summarizes the current research status of NK cell therapy in clinical applica-tions,highlighting its promising efficacy and safety as an innovative immunotherapy.Despite challenges such as limited cell persistence and tumor microenvironment suppression,the prospects for further development in this field remain promising.
