Research progress of CMPK2 in responding to pathogenic infections and regula-ting inflammation
10.16303/j.cnki.1005-4545.2025.01.23
- VernacularTitle:CMPK2应对病原感染与调控炎症的研究进展
- Author:
Chanyu WU
1
;
Qiuyue PENG
1
;
Xiaoxin NIU
1
;
Zuoyong ZHOU
1
Author Information
1. 西南大学动物医学院,重庆荣昌 402460
- Publication Type:Journal Article
- Keywords:
CMPK2;
pathogenic infection;
inflammatory regulation
- From:
Chinese Journal of Veterinary Science
2025;45(1):170-174
- CountryChina
- Language:Chinese
-
Abstract:
Cytidine/uridine monophosphate kinase 2(CMPK2)is an interferon-stimulated gene that plays an important role against viral infections.CMPK2 is also a rate-limiting enzyme in mitochon-dria that maintains intracellular levels of UTP/CTP and can affect inflammation triggered by path-ogenic infections and other causes of alterations in mitochondria.In this article,we review the structure and distribution of CMPK2,its role in responding to pathogenic infections and the regu-lation of inflammation,and the associated signaling pathways.
