Clinical manifestations and drug resistance analysis of 36 neonates with enterobacter sepsis
10.3760/cma.j.cn431274-20241011-01533
- VernacularTitle:36例新生儿肠杆菌败血症临床表现及耐药分析
- Author:
Yan YANG
1
;
Haifeng GENG
1
;
Shenglin YU
1
;
Xueping ZHU
1
Author Information
1. 苏州大学附属儿童医院新生儿科，苏州 215000
- Publication Type:Journal Article
- Keywords:
Neonatal septicemia;
Enterobacteriaceae infections;
Drug resistance
- From:
Journal of Chinese Physician
2025;27(10):1468-1472
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize and analyze the clinical characteristics, drug resistance and treatment of 36 neonates with Enterobacter sepsis in the Children′s Hospital of Soochow University in the past 3 years, so as to provide reference for clinical treatment.Methods:A retrospective analysis was conducted on neonates hospitalized in the Department of Neonatology of the Children′s Hospital of Soochow University from January 2021 to March 2024 who were diagnosed with Enterobacter sepsis. The birth status, clinical manifestations, blood culture drug sensitivity, treatment status and disease outcome of the neonates were analyzed.Results:A total of 36 neonates with Enterobacter sepsis were collected. Premature infants accounted for 38.9%(14/36), and late-onset cases accounted for 66.7%(24/36). The incidence of complications was high. The main complications were central nervous system infection (15/36, 41.7%), urinary system infection (13/36, 36.1%) and neonatal necrotizing enterocolitis (7/36, 19.4%). The main pathogenic bacteria were Escherichia coli (19 cases) and Klebsiella (11 cases). Among the 19 escherichia coli strains, 7 were extended-spectrum β-lactamase (ESBL)-producing strains and 1 was carbapenem-resistant enterobacteriaceae (CRE) strain. Among the 11 Klebsiella strains, 9 were ESBL-producing strains and 6 were CRE strains. The 6 neonates with CRE sepsis were treated with sensitive antibiotics such as meropenem, amikacin and ceftazidime-avibactam, and achieved good therapeutic effects.Conclusions:Escherichia coli and Klebsiella are the main pathogens of Enterobacter sepsis in neonates, especially premature infants, with high incidence of complications and high drug resistance rate.
