Diagnostic value of 18F-FDG PET/CT and bone marrow biopsy in evaluating common non-Hodgkin lymphoma with bone marrow infiltration
10.12007/j.issn.0258-4646.2025.05.010
- VernacularTitle:18F-FDG PET/CT和骨髓活检对常见非霍奇金淋巴瘤骨髓浸润的诊断价值
- Author:
Bin HU
1
;
Liu HE
;
Yang LI
;
Cheng GU
;
Xiaoming ZHANG
;
Lichun ZHENG
Author Information
1. 唐山市工人医院核医学科,河北 唐山 063000;河北医科大学研究生学院,石家庄 050000
- Publication Type:Journal Article
- Keywords:
non-Hodgkin lymphoma;
positron emission tomography;
computed tomography;
18F-FDG;
bone marrow biopsy;
bone marrow infiltration
- From:
Journal of China Medical University
2025;54(5):437-441,447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of positron emission tomography(PET)/computed tomography(CT)and bone marrow biopsy(BMB)for bone marrow infiltration in common non-Hodgkin lymphoma(NHL).Methods We retrospectively analyzed data from 197 patients with NHL and compared the diagnostic value of PET/CT and BMB for bone marrow infiltration.Differences in PET/CT parameters and serological test results were compared between PET/CT-positive and PET/CT-negative patients as well as between BMB-positive and BMB-negative patients.Results In patients with diffuse large B-cell lymphoma(DLBCL),the sensitivities of PET/CT and BMB for detecting bone marrow infiltration were 90.5%and 66.7%,and the specificities were 95.1%and 100.0%,respectively.In patients with follicular lymphoma(FL),the sensitivities were 63.6%and 81.8%,and the specificities were 98.1%and 100.0%,respec-tively.In patients with T-cell lymphoma(TCL),the sensitivities were 60.0%and 80.0%,and the specificities were 88.0%and 100.0%,respectively.Among patients with DLBCL and TCL,significant differences were observed in platelet count and lactate dehydrogenase levels between PET/CT-positive and PET/CT-negative patients(P<0.05).Conclusion PET/CT showed excellent diagnostic perfor-mance for evaluating bone marrow infiltration in DLBCL.PET/CT had limited sensitivity for FL and TCL and might serve as a supplemen-tary tool for BMB.Platelet count and lactate dehydrogenase levels may aid in the diagnosis of bone marrow infiltration in DLBCL and TCL.
