Early changes of left atrial strain and left atrial stiffness index in rabbits with left ventricular myocardial injury induced by adriamycin
10.13929/j.issn.1672-8475.2025.05.009
- VernacularTitle:阿霉素致左心室心肌损伤兔早期左心房应变及左心房僵硬度指数改变
- Author:
Jiahao WEI
1
;
Xuebing LIU
1
;
Qingguo MENG
1
;
Zhaohuan LI
1
;
Linyi LYU
1
Author Information
1. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)心血管超声及心功能科超声心脏电生理学与生物力学四川省重点实验室,四川 成都 610072
- Publication Type:Journal Article
- Keywords:
rabbits;
doxorubicin;
ventricular function,left;
atrial function,left;
echocardiography
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(5):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe early changes of left atrial strain and left atrial stiffness index(LASI)in rabbits with left ventricular myocardial injury induced by adriamycin(ADM).Methods Eighteen New Zealand white rabbits were randomly divided into experimental group(n=12)and control group(n=6),while 2 mg/kg ADM was injected into rabbits in experimental group and 5 ml physiological saline was injected into rabbits in control group every week for a total of 4 weeks.Ultrasound examination was performed before injection of ADM/physiological saline,2 and 4 weeks after injection,respectively.Left atrial anteroposterior diameter(LAAPD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),lateral wall of mitral ring of early peak flow velocity(e),mitral valve orifice early peak flow velocity(E)/e,left ventricular global longitudinal strain(LVGLS),right ventricular collectivity long axis strain(RVCLS),left atrial strain during reservoir phase(LASr),left atrial strain during conduit phase(LAScd),left atrial strain during contraction phase(LASct)and LASI were obtained and analyzed.After ultrasound examination,myocardial changes were observed with pathological examination.Results Four weeks after injection,e in experimental group was significantly lower than that before injection,also lower than that 2 and 4 weeks after injection in control group(all P＜0.05).Significant differences of LASr,LAScd,LASct and LASI were found among different time points between groups(all P＜0.05).Two and 4 weeks after injection,the above 4 parameters in experimental group were all significantly different with those in control group(all P＜0.05).LASr,LASct and LASI were different among different time points,while LAScd before injection was higher than that 2 and 4 weeks after injection in experimental group(all P＜0.05).The pathological findings supported ultrasonic changes.Conclusion In early stage of ADM induced left ventricular myocardial injury in rabbits,changes of left atrial strain and LASI could be seen,which were more significant than those of LVGLS,RVCLS and LVEF,etc.
