Value of acid-base indicators and strong ion gap in evaluating prognosis of patients with acute paraquat poisoning
10.3760/cma.j.cn431274-20241211-01846
- VernacularTitle:酸碱指标和强离子隙评估急性百草枯中毒患者预后的价值
- Author:
Weiwei LYU
1
;
Ling DING
1
;
Yanli WANG
1
Author Information
1. 连云港市第一人民医院急诊内科，连云港 222000
- Publication Type:Journal Article
- Keywords:
Paraquat poisoning;
Acid-base equilibrium;
Strong ion gap;
Prognosis
- From:
Journal of Chinese Physician
2025;27(10):1489-1492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of acid-base indicators and strong ion gap (SIG) in the prognostic diagnosis of patients with acute paraquat poisoning (APP).Methods:The medical records of 78 APP patients admitted to the First People′s Hospital of Lianyungang from March 2021 to March 2024 were analyzed retrospectively. The patients were divided into the death group ( n=56) and the survival group ( n=22) according to their prognosis. Clinical data, acid-base indicators, and SIG levels were compared between the two groups. Logistic regression analysis was used to identify the influencing factors of prognosis in APP patients and construct a nomogram. Receiver operating characteristic (ROC) curve was established to analyze the diagnostic value of combined acid-base indicators and SIG for the prognosis of APP patients. Results:There were no statistically significant differences in gender, age, body mass index, time from poisoning to treatment, history of diabetes, or history of hypertension between the two groups (all P>0.05). The levels of anion gap (AG), bicarbonate ion (HCO 3-), lactic acid (Lac), and SIG in the death group were higher than those in the survival group (all P<0.05). Logistic regression analysis showed that AG, HCO 3-, Lac, and SIG levels were influencing factors for the prognosis of APP patients (all P<0.05). ROC curve results indicated that the area under the curve (AUC) of AG, HCO 3-, Lac, and SIG combined in predicting the prognosis of APP patients was significantly higher than that of single prediction. Conclusions:Acid-base indicators and SIG have good diagnostic value for the prognosis of APP patients.
