Diagnostic value of D-dimer combined with NT-proBNP in the occurrence of renal dysfunction in ACS pa-tients
10.3969/j.issn.1006-5725.2025.05.018
- VernacularTitle:D-二聚体联合NT-proBNP对急性冠脉综合征患者发生肾功能不全的诊断价值
- Author:
Wenlu FAN
1
;
Xiaoyu DU
;
Chengzhi LU
Author Information
1. 天津医科大学一中心临床学院(天津 300192);中国人民解放军北京卫戍区东城第一离职干部休养所(北京 100120)
- Publication Type:Journal Article
- Keywords:
D-dimer;
N-terminal pro-B-type natriuretic peptide;
acutecoronarysyndrome;
valuere-search
- From:
The Journal of Practical Medicine
2025;41(5):736-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study aimed to explore the clinical diagnostic value of D-Dimer(D-D)com-bined with N-terminal pro-B-type natriuretic peptide(NT-proBNP)in the occurrence of renal dysfunction in patients with acute coronary syndrome(ACS).Methods As a retrospective cohort study,we selected 682 patients as the research subjects.The patients were with acute coronary syndrome who visited the Chest Pain Center of Tianjin First Central Hospital during January 2021 and December 2023.Based on the eGFR values calculated from the creatinine levels before coronary angiography,patients were divided into the renal insufficiency group and the normal renal function group,comprising 102 cases and 580 cases,respectively.Binary logistic regression was adopted to analyze the influence factors of renal dysfunction in ACS patients,and the receiver operating characteristic(ROC)curve was utilized to evaluate the diagnostic value of D-D and NT-proBNP levels for renal dysfunction in ACS patients.Results The levels of D-D and NT-proBNP in the renal insufficiency group were significantly higher than those in the normal renal function group(P<0.05).Univariate logistic regression analysis showed that the rise of D-D and NT-proBNP levels were both independent risks for renal dysfunction in ACS patients.Multivariate logistic regression analysis indicated that the combined detection of D-D and NT-proBNP was an independent risk factor for renal dysfunction in ACS patients.The ROC results showed that the AUC,sensitivity,and specificity of the D-D level in diagnosing renal dysfunction in ACS patients were 0.805,58.82%,and 100%,respectively.The AUC,sensitivity,and specificity of NT-proBNP level in diagnosing renal dysfunction after myocardial infarction in ACS patients were 0.737,67.65%,and 73.62%,respectively.The AUC,sensitivity,and specificity of D-D combined with NT-proBNP in diagnosing renal dysfunction in ACS patients were 0.838,68.63%,and 93.28%,respectively.The diagnostic value of combined detection was superior to that of individual testing.Conclusions The levels of D-D and NT-proBNP were significantly elevated in ACS patients with renal dysfunction,which were independent risk factors for the occurrence of renal dysfunction,and the combined detection could help diagnose renal dysfunction.
