Impact of endoscopic retrograde cholangiopancreatography combined with electrohydraulic lithotripsy on liver function and energy metabolism in patients with extrahepatic biliary stones
10.3760/cma.j.cn431274-20240807-01210
- VernacularTitle:内镜逆行胰胆管造影术联合液电碎石术对肝外胆管结石患者肝功能与能量代谢的影响
- Author:
Bin FAN
1
;
Fei WANG
;
Yangchao WEI
;
Shengli HUANG
;
Laishe LU
Author Information
1. 中国人民解放军空军军医大学第一附属医院肝胆外科，西安 710001
- Publication Type:Journal Article
- Keywords:
Cholangiopancreatography, endoscopic retrograde;
Electrohydraulic lithotripsy;
Extrahepatic bile duct stones;
Liver function;
Energy metabolism
- From:
Journal of Chinese Physician
2025;27(9):1309-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of endoscopic retrograde cholangiopancreatography (ERCP) combined with electrohydraulic lithotripsy on liver function and energy metabolism in patients with extrahepatic biliary stones.Methods:A prospective study was conducted on 85 patients with extrahepatic biliary stones treated in four tertiary grade A hospitals (the First Affiliated Hospital of Air Force Medical University, Baoji Central Hospital, Xi′an No. 1 Hospital Wenli Hospital, and Affiliated Hospital of North China University of Science and Technology) from January 2020 to January 2024. They were divided into a control group ( n=43, treated with ERCP) and a combined group ( n=42, treated with ERCP combined with electrohydraulic lithotripsy) using a random number table. The main evaluation indicators included liver function, energy metabolism parameters, stress levels, and postoperative complications. Results:There were no statistically significant differences in liver function indicators, energy metabolism parameters, or stress levels between the two groups before surgery (all P>0.05). At 3 days after surgery, liver function indicators in both groups were lower than those before surgery, and the liver function indicators in the combined group were all lower than those in the control group (all P<0.05). At 1 day after surgery, REE in both groups was higher than that before surgery, and RQ was lower than that before surgery; the REE in the combined group was lower than that in the control group, and the RQ in the combined group was higher than that in the control group (all P<0.05). At 3 days after surgery, the levels of Cor and ACTH in both groups were higher than those before surgery, and the Cor and ACTH in the combined group were lower than those in the control group (all P<0.05). The incidence of postoperative complications in the combined group was significantly lower than that in the control group ( P<0.05). Conclusions:ERCP combined with electrohydraulic lithotripsy can effectively improve liver function and energy metabolism, reduce inflammatory response in patients with extrahepatic biliary stones, and is safe for treatment, which is suitable for clinical promotion and application.
