Review on Hemocompatibility Risk Assessment Models for Artificial Heart
10.16156/j.1004-7220.2025.01.002
- VernacularTitle:人工心脏血液损伤风险评估模型综述
- Author:
Yuan LI
1
;
Zengsheng CHEN
1
Author Information
1. 生物力学与力生物学教育部重点实验室;高端医疗装备与器械创新及转化工业和信息化部重点实验室;国家医学攻关(医工结合方向)高端医疗装备与器械产教融合创新平台;北京航空航天大学生物与医学工程学院,北京 100191
- Publication Type:Journal Article
- Keywords:
artificial heart;
mathematical models;
thrombosis;
bleeding;
shear stress
- From:
Journal of Medical Biomechanics
2025;40(1):13-24
- CountryChina
- Language:Chinese
-
Abstract:
As a critical treatment for patients with end-stage heart failure,artificial hearts have achieved significant clinical success.However,due to the direct contact between mechanical blood pumps and circulating blood,the clinical use of artificial hearts is often associated with blood damage-related complications such as thrombosis and bleeding,which significantly affect patient outcomes and prognosis.This paper first systematically reviews the mechanisms of blood damage induced by artificial hearts,including the biomechanical processes of platelet activation caused by non-physiological shear stress,von Willebrand factor(vWF)degradation,and platelet receptor impairment.Subsequently,existing thrombosis risk assessment models are summarized in detail,including blood stasis models,platelet activation models,and advanced mathematical models incorporating dynamic changes in coagulation factors and hemostatic proteins.These models predict high-risk thrombosis regions induced by artificial hearts,providing valuable guidance for device optimization and complication prevention.Finally,recently developed bleeding risk assessment models for artificial hearts are introduced.The integration of bleeding and thrombosis risk models enables the development of a more comprehensive hemocompatibility evaluation system.By reviewing the current research progress,this study aims to provide a reference for the assessment and prediction of blood damage in artificial hearts,contributing to improved hemocompatibility,enhanced safety,and better clinical outcomes of artificial heart devices.
