Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine
10.3969/j.issn.1006-5725.2025.05.005
- VernacularTitle:昼夜节律基因调控消化系统肿瘤及中药干预作用的研究进展
- Author:
Shuo SUN
1
;
Wenjie ZHANG
;
Yi ZHAO
;
Youzhi SUN
Author Information
1. 江西中医药大学中医学院·生命科学学院(江西 南昌 330004)
- Publication Type:Journal Article
- Keywords:
circadian rhythm;
circadian clock genes;
digestive system tumors;
traditional Chinese medicine;
mechanism
- From:
The Journal of Practical Medicine
2025;41(5):648-656
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythms,a result of the long-term evolution of organisms adapting to the Earth′s environment,play a crucial regulatory role in biological activities.Disruptions in circadian rhythms have been iden-tified as potential carcinogenic risk factors,closely linked to the pathological states of digestive system diseases,and significantly contribute to the occurrence and progression of digestive system tumors.These rhythms not only influence the regulation of cell cycles,proliferation,and apoptosis of tumor cells but also profoundly affect their migratory abilities,immune functions,and drug resistance.This article focuses on the specific regulatory mechanisms of circadian rhythm genes in relation to digestive system tumors and comprehensively summarizes research findings on the anti-tumor effects of traditional Chinese medicine targeting these circadian clock genes.The aim is to provide new avenues for target selection and prognostic evaluation in the treatment of digestive system tumors.
