Research progress on iron metabolism imbalance and ferroptosis in chronic obstructive pulmonary disease

VernacularTitle:慢性阻塞性肺疾病中铁代谢失衡及铁死亡的研究进展
Author: Ke ZHAO ¹ ; Min LI ; Ning WANG ; Hong SUO
Author Information

1. 内蒙古医科大学研究生院，呼和浩特　010000
Publication Type:Journal Article
Keywords: Pulmonary disease, chronic obstructive; Ferroptosis; Iron metabolism
From: Journal of Chinese Physician 2025;27(8):1273-1277
CountryChina
Language:Chinese
Abstract: Chronic obstructive pulmonary disease (COPD) is a common and frequently-occurring respiratory disease, which has imposed a huge burden on society. Moreover, the pathogenesis of COPD remains unclear. Ferroptosis is a newly discovered pattern of programmed cell death, characterized by excessive iron accumulation and lipid peroxidation. Studies have shown that ferroptosis and abnormal iron metabolism play an indispensable role in COPD. This article reviews the relationship between ferroptosis and COPD, elaborates on the impact of iron metabolism imbalance in the body on the occurrence and development of COPD, in order to stimulate the thinking of a large number of researchers and reveal the crucial role of iron in COPD.