Levels of serum thymic stromal lymphopoietin and double-negative T lymphocytes in children with bronchial asthma and their clinical significance
10.3760/cma.j.cn431274-20240613-00930
- VernacularTitle:支气管哮喘儿童血清胸腺基质淋巴细胞生成素、双阴性T淋巴细胞水平及临床意义
- Author:
Long ZHAO
1
;
Jing WANG
1
;
Cuicui LIU
1
;
Xiaolan SHI
1
Author Information
1. 西安市儿童医院呼吸哮喘中心，西安 710000
- Publication Type:Journal Article
- Keywords:
Asthman;
Thymic stromal lymphopoietin;
Double negative T lymphocytes;
Asthma control
- From:
Journal of Chinese Physician
2025;27(7):1019-1023
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the levels of serum thymic stromal lymphopoietin (TSLP) and double-negative T lymphocytes (DNT) in children with bronchial asthma and their clinical significance.Methods:The clinical data of 147 children with bronchial asthma (study group) diagnosed and treated in Xi′an Children′s Hospital from January to March 2024 were retrospectively analyzed, and the clinical data of 120 children who underwent healthy physical examination in the hospital during the same period (control group) were selected. All subjects underwent serum TSLP and DNT detection. The study group was divided into controlled group (116 cases) and uncontrolled group (31 cases) according to the asthma control level. The levels of TSLP and DNT were compared between the two groups, and the factors affecting the asthma control level in children with bronchial asthma were analyzed. Receiver operating characteristic (ROC) curve was used to analyze the value of TSLP and DNT in predicting the asthma control level in children.Results:The serum TSLP level in the study group was higher than that in the control group, and the DNT level was lower than that in the control group (all P<0.05). The TSLP level, the proportion of severe cases, and the proportion of cases with family history of asthma in the uncontrolled group were higher than those in the controlled group, while the DNT level, age, and forced expiratory volume in the first second/forced vital capacity (FEV 1/FVC) were lower than those in the controlled group (all P<0.05). Multivariate stepwise logistic regression analysis showed that TSLP level ( OR=3.656, 95% CI: 2.091-6.392) and disease severity ( OR=2.561, 95% CI: 1.230-5.330) were independent risk factors affecting asthma control level in children, while DNT level ( OR=0.233, 95% CI: 0.122-0.442) and FEV 1/FVC level ( OR=0.287, 95% CI: 0.127-0.647) were independent protective factors (all P<0.05). ROC curve analysis showed that the sensitivities of TSLP, DNT, and their combination in predicting asthma control level were 74.20%, 71.00%, and 90.30% respectively; the specificities were 75.90%, 73.30%, and 91.40% respectively; the areas under the curve (AUC) were 0.821, 0.805, and 0.923 respectively (all P<0.05). Conclusions:Serum TSLP level is abnormally increased and DNT level is abnormally decreased in children with bronchial asthma. TSLP is an independent risk factor affecting asthma control level in children, and DNT is an independent protective factor. Combined detection of TSLP and DNT can better predict the asthma control status of patients in clinical practice.
