Effect of ultra-pure double-lumen dialyzer combined with online hemodiafiltration on microinflammatory state in maintenance hemodialysis patients
10.3760/cma.j.cn431274-20240519-00819
- VernacularTitle:超纯双腔透析器配对在线透析滤过对维持性血液透析患者微炎症状态的影响
- Author:
Qi WANG
1
;
Weibin HUANG
1
;
Zihan LEI
1
;
Jiaqi XU
1
;
Yuquan WANG
1
;
Pei YANG
1
Author Information
1. 广州市花都区人民医院肾病学科，广州 510800
- Publication Type:Journal Article
- Keywords:
Hemodiafiltration;
Inflammation
- From:
Journal of Chinese Physician
2025;27(7):1014-1018
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the intervention effect of ultra-pure double-lumen dialyzer paired with online hemodiafiltration (PHF) on the microinflammatory state in maintenance hemodialysis patients.Methods:A total of 112 maintenance hemodialysis patients admitted to the Huadu District People′s Hospital of Guangzhou from January 2020 to December 2023 were prospectively enrolled. Using a parallel control and before-after control method, the patients were divided into an observation group and a control group according to the odd and even numbers of their enrollment sequence, with 56 cases in each group. The observation group received PHF during hemodiafiltration, while the control group received hemodiafiltration with a high-flux dialyzer. Venous blood samples were collected from both groups before treatment and 6 months after treatment to detect the levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon (IFN)-γ. The dialysis efficacy of the two groups was compared by evaluating the changes in microinflammatory index levels.Results:Before treatment, there were no significant differences in serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and hs-CRP between the two groups (all P>0.05). After treatment, various inflammatory indicators in the observation group were significantly lower than those before treatment (all P<0.05), while there were no significant differences in inflammatory indicators in the control group before and after treatment (all P>0.05). Moreover, there were significant differences in inflammatory indicators between the observation group and the control group after treatment ( P<0.05). Conclusions:Ultra-pure double-lumen dialyzer paired with online hemodiafiltration can significantly improve the inflammatory state in hemodialysis patients.
