Research progress in anti-inflammatory mechanisms of targeting pyruvate kinase M2
10.3867/j.issn.1000-3002.2025.08288
- VernacularTitle:靶向丙酮酸激酶M2的抗炎机制研究进展
- Author:
Mengmeng ZHANG
1
;
Liangliang SHEN
;
Xuan QU
Author Information
1. 陕西中医药大学基础医学院,陕西 咸阳 712046
- Publication Type:Journal Article
- Keywords:
inflammatory response;
pyruvate kinase M2;
glycolysis;
lactylation;
macrophage
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(7):550-558
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory response is a natural defense mechanism of the body that occurs in response to infection or injury,serving as a critical starting point for the onset and progression of various diseases.Glycolysis,an essential pathway for energy production within the body,plays a pivotal role in both the initiation and advancement of the inflammatory response.Pyruvate kinase M2(PKM2),recog-nized as a key rate-limiting enzyme in glycolysis,not only contributes to the inflammatory process by mediating glycolysis and lactylation modifications through such mechanisms as nuclear translocation and dimer formation,but also regulates the inflammatory response by modulating immune responses in B cells,T cells,macrophages,and neutrophils.This review aims to summarize the mechanisms involved in targeting PKM2 to suppress inflammation,providing new insights into the prevention and treatment of inflammatory reactions.
