Research progress in therapeutic targets and drugs for eosinophilic gastroenteritis
10.3867/j.issn.1000-3002.2025.08291
- VernacularTitle:嗜酸性粒细胞胃肠炎的治疗靶点及药物研究进展
- Author:
Xinyi ZHANG
1
;
Yinru JIANG
1
;
Ziyuan ZHAO
1
;
Longrui WANG
1
;
Wenjing SUN
1
;
Guanhua DU
1
;
Linglei KONG
1
Author Information
1. 中国医学科学院北京协和医学院药物研究所,北京市药物靶点研究与新药筛选重点实验室,北京 100050
- Publication Type:Journal Article
- Keywords:
gastroenteritis;
eosinophils;
allergic reaction;
therapeutic targets;
therapeutic drugs
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(7):538-549
- CountryChina
- Language:Chinese
-
Abstract:
Eosinophilic gastroenteritis(EG)is a rare disease characterized by abnormal infiltration of eosinophils(Eos)in gastrointestinal tissues.Due to the unclear pathogenesis of EG and the lack of effective therapeutic drugs,research on its novel mechanisms,targets and drugs is critical.This article starts by outlining the research progress in the pathogenesis of EG,involving IgE mediated typeⅠimmediate allergic reactions and T helper 2 cell(Th2)mediated delayed allergic reactions.Then,the related targets of EG are summarized,including Th2 cytokines and factors regulating Eos function,but there has been no breakthrough in the treatment of these targets.Finally,the therapeutic drugs for EG are reviewed,such as glucocorticoids,antiallergic drugs and biologics.The advantages and disadvantages of various drugs are also described.However,these drugs cannot meet the current demands of clinical treatment and there is an urgent need to develop novel therapeutic drugs.It is believed that multi-target therapy is an ideal treatment for EG,and that traditional Chinese medicine and natural products should be the priorities of research and development for EG therapeutic drugs in the future.This review is expected to provide new ideas for the clinical treatment strategies and drug development of EG.
