Research progress on the role of transcription factor SOX9 in cardiovascular system
10.20039/j.cnki.1007-3949.2025.06.010
- VernacularTitle:转录因子SOX9在心血管系统中的作用研究进展
- Author:
Huiying WANG
1
;
Yushu LIU
;
Yong ZHAO
;
Yu FU
Author Information
1. 哈尔滨医科大学附属第一医院心血管内科,黑龙江省 哈尔滨市 150001
- Publication Type:Journal Article
- Keywords:
cardiovascular diseases;
SRY-related high mobility group-box9;
cardiac development;
cardiac remodeling;
vascular remodeling
- From:
Chinese Journal of Arteriosclerosis
2025;33(6):531-538
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is an important problem affecting global human health,and its incidence is in-creasing year by year.In recent years,more and more studies have shown that sex-determined region of Y(SRY)-related high mobility group-box 9(SOX9)gene,as a highly conserved transcription factor,is widely involved in regulating cardiac dvelopment and cardiovascular disease progression at the level of gene transcription.SOX9,alone or in combination with other proteins,can bind to corresponding cis-acting elements in the downstream target gene promoter region and participate in regulating the expression of downstream heart development or cardiovascular disease-related genes.Therefore,SOX9 has the potential to be a new therapeutic target for the cardiovascular system.In this paper,the structure and function of SOX9 were systematically described,and the latest research progress of SOX9 in cardiac remodeling and vascular remode-ling was summarized,in order to provide new ideas and methods for the prevention and treatment of cardiovascular system diseases in the future.
