Relationship between the expressions of long noncoding RNA HOXA11-AS and LEF1-AS1 in hypopharyngeal carcinoma tissues and prognosis
10.3760/cma.j.cn431274-20240604-00895
- VernacularTitle:下咽癌组织长链非编码RNA HOXA11-AS、LEF1-AS1表达与预后的关系
- Author:
Longchao QIN
1
;
Qian ZHAO
1
;
Xueyan REN
1
;
Kaili SUN
1
;
Jiaojiao REN
1
;
Lina PENG
1
;
Haiping HAN
1
Author Information
1. 邯郸市中心医院耳鼻咽喉头颈外科二科，邯郸 056000
- Publication Type:Journal Article
- Keywords:
Hypopharyngeal neoplasms;
RNA, long noncoding;
HOXA11-AS;
LEF1-AS1;
Prognosis
- From:
Journal of Chinese Physician
2025;27(7):994-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expressions of long noncoding RNA (lncRNA) homeobox A11 antisense RNA (HOXA11-AS) and lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) in hypopharyngeal carcinoma tissues and their relationships with prognosis.Methods:Prospectively, 80 patients with hypopharyngeal carcinoma who were treated in Handan Central Hospital from February 2019 to February 2021 were selected. The hypopharyngeal carcinoma tissues resected surgically and the adjacent normal tissues (more than 2 cm away from the edge of the cancer tissue) were obtained. The expressions of HOXA11-AS and LEF1-AS1 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). The expressions of HOXA11-AS and LEF1-AS1 in hypopharyngeal carcinoma tissues and adjacent normal tissues were compared. The relationships between their expressions and clinicopathological features were analyzed. The Kaplan-Meier method was used to analyze the relationships between high/low expressions of HOXA11-AS and LEF1-AS1 and the prognosis of patients with hypopharyngeal carcinoma.Results:The expressions of HOXA11-AS and LEF1-AS1 in hypopharyngeal carcinoma tissues were higher than those in adjacent normal tissues (all P<0.05). The expressions of HOXA11-AS and LEF1-AS1 in hypopharyngeal carcinoma tissues were related to tumor node metastasis (TNM) stage, degree of differentiation, and lymph node metastasis (all P<0.05). The 3-year overall survival rates of patients with high expressions of HOXA11-AS and LEF1-AS1 in hypopharyngeal carcinoma tissues were lower than those of patients with low expressions (all P<0.05). Conclusions:The expressions of HOXA11-AS and LEF1-AS1 are increased in hypopharyngeal carcinoma tissues, which are related to poor prognosis of patients with hypopharyngeal carcinoma.
