Assessment of causal direction between gut microbiota andbreast malig-nancy:a two-sample mendelian randomization
10.3969/j.issn.1009-9905.2025.02.003
- VernacularTitle:肠道微生物与乳房恶性肿瘤的因果关系:双样本孟德尔随机化分析
- Author:
Shuang LIANG
1
;
Wen-jing LIAN
;
Hong-yi LIANG
;
Jing-wei LI
Author Information
1. 山东中医药大学第一临床医学院(山东 济南 250014)
- Publication Type:Journal Article
- Keywords:
Mammary neoplasia;
Gut microbiota;
Mendelian randomization;
Causality
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(2):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Elucidating causal links between gut microbiota and breast malignancies using mendelian randomization(MR)to Identify specific causal microbial taxa.Methods:Genome-wide association studies(GWAS)summary statistics on gut microbiota and breast malignancies,MiBioGen studied GWAS(N=18473)as exposure samples,and GWAS(N=123579)of breast malignancies in the IEU Open GWAS database as outcome samples.The in-verse variance weighted(IVW),weighted median and MR-Egger methods were used to analyze the MR statistical re-suits.Results:Increased abundance of Pasteurellales increased the risk of breast malignancy(IVW PFDR＜0.05,OR=1.21,95％Cl:1.07～1.36),heterogeneity test and pleiotropy test showed no effect on causality,and the"leave-one-out"method showed that the identified causal association was not driven by any single instrumental variable.The causal relationship is positive.Conclusion:Elevated abundance of pasteurellales in the gut microbiota is associated with an increased risk of breast malignancies
