Mechanism progress of monocyte-derived immune cells and their secreted cytokines on development and metastasis of breast cancer
10.3867/j.issn.1000-3002.2025.08323
- VernacularTitle:单核源性免疫细胞及其分泌的细胞因子影响乳腺癌发展和转移的作用机制研究进展
- Author:
Xiangnuo CHEN
1
;
Yuhao YE
;
Ninghui MA
;
Yang XIONG
Author Information
1. 浙江中医药大学药学院,浙江 杭州 311402
- Publication Type:Journal Article
- Keywords:
monocyte-derived immune cells;
breast cancer progression;
breast cancer metastasis;
cytokine;
immune regulation;
tumor microenvironment
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(7):527-537
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is a highly prevalent malignant tumor among women worldwide,and its clinical treatment faces significant challenges,such as high postoperative recurrence rates,high metas-tasis rates,and therapeutic resistance.Studies indicate that monocyte-derived immune cells play a critical role in promoting breast cancer progression by establishing an immunosuppressive tumor microenviron-ment and pre-metastatic niche.Monocytic myeloid-derived suppressor cells,tumor-associated macro-phages,and monocyte-derived dendritic cells secrete various cytokines,including interleukins,colony-stimulating factors,tumor necrosis factor,chemokines C-C motif chemokine ligand/C-X-C motif chemo-kine ligand(CCL/CXCL),and growth factors,which activate multiple signaling pathways and promote the development of breast cancer and its metastasis to such organs as bones,lungs,brains and livers through mechanisms involving CCL/CXCL-mediated recruitment,angiogenesis induction,and immune evasion.Therefore,targeting the regulation of monocyte-derived immune cells and their secreted cyto-kines may become a crucial therapeutic approach to breast cancer.This review summarizes the mech-anisms by which monocyte-derived immune cells and their cytokines contribute to the development and metastasis of breast cancer by exploring.It further explores therapeutic strategies targeting these cells and cytokines,such as modulating phenotypic transformation,reprogramming cellular metabolism,and regulating cytokine expression levels.
