Correlation between expression of hepatoma-derived growth factor and prognosis of patients with oral cancer
10.3760/cma.j.cn431274-20240205-00249
- VernacularTitle:肝癌衍生生长因子的表达与口腔癌患者预后的相关性
- Author:
Yiqi LIU
1
;
Hui ZHANG
;
Tiankun WANG
Author Information
1. 东南大学医学院附属南京同仁医院口腔科，南京 210000
- Publication Type:Journal Article
- Keywords:
Hepatoma-derived growth factor;
Mouth neoplasms
- From:
Journal of Chinese Physician
2025;27(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the expression of hepatoma-derived growth factor (HDGF) and the prognosis of patients with oral cancer.Methods:Clinical data of 96 patients with oral cancer admitted to Nanjing Tongren Hospital, School of Medicine, Southeast University from March 2019 to January 2023 were retrospectively analyzed, and biopsy cancer tissue specimens and adjacent tissues >3 cm from the tumor margin of oral cancer patients were collected. The expression of HDGF in cancer tissues and adjacent tissues was compared, and the influence of HDGF expression on prognosis of patients was analyzed. The patients were followed up for 36 months to compare the survival rate of patients with HDGF-negative and HDGF-positive oral cancer during follow-up.Results:The positive expression rate of HDGF in oral cancer tissues [75.00%(72/96)] was higher than that in adjacent tissues [11.46%(11/96)] ( P<0.05). There was no significant difference in the positive expression rate of HDGF in oral cancer patients with different sex, age, body mass index (BMI), smoking and drinking conditions ( P>0.05). The positive expression rate of HDGF in oral cancer tissues of patients with tumor length ≥3 cm, clinical stage Ⅲ-Ⅳ, lymph node metastasis, low differentiation, and vascular invasion was higher than that of patients with tumor length <3 cm, clinical stageⅠ-Ⅱ, no lymph node metastasis, medium/high differentiation, and no vascular invasion (all P<0.05). Cox regression analysis showed that tumor length, periodontitis or pulpitis, smoking, clinical stage, lymph node metastasis, histological type and positive expression of HDGF were independent influencing factors for overall survival of patients with oral cancer (all P<0.05). By the end of follow-up, the overall survival rate of patients with positive expression of HDGF was 70.77%(46/65), and that of patients with negative expression of HDGF was 95.45%(21/22). The survival rate of patients with negative expression of HDGF was higher than that of patients with positive expression ( P<0.05). Conclusions:The expression of HDGF in oral cancer tissues is abnormally high, which is closely related to clinicopathological features and prognosis.
