Research progress of pyroptosis in the initiation and progression of atherosclerosis
10.20039/j.cnki.1007-3949.2025.06.012
- VernacularTitle:细胞焦亡在动脉粥样硬化发生发展中的研究进展
- Author:
Tingting SHANG
1
;
Cuiping WANG
1
;
Rui CAI
1
;
Lin ZHOU
1
Author Information
1. 江苏大学附属医院心内科,江苏省 镇江市 212000
- Publication Type:Journal Article
- Keywords:
pyroptosis;
inflammation;
atherosclerosis;
endothelial cell;
vascular smooth muscle cell;
macrophage;
target
- From:
Chinese Journal of Arteriosclerosis
2025;33(6):546-552
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a form of programmed cell death characterized by prominent inflammatory responses.As a classic chronic inflammatory disease,atherosclerosis(As)has been demonstrated to exhibit specific expression of multiple pyroptosis-related proteins within plaques.Accumulating evidence indicates that pyroptosis plays a crucial regulatory role in the initiation and progression of As.This review primarily focuses on three key cell types involved in As—endothelial cell,macrophage,and vascular smooth muscle cell(VSMC),and systematically summarizes their pyroptotic mechanisms and contributions to atherosclerotic development.Furthermore,we comprehensively summarize current advances in anti-atherosclerotic drugs and bioactive compounds targeting pyroptosis,aiming to provide theoretical foundations and research perspectives for developing novel strategies for the prevention and treatment of As.
