Liver fibrosis/cirrhosis and mesenchymal stem cells:from pathogenesis to treatment
10.3969/j.issn.1009-9905.2024.12.001
- VernacularTitle:肝纤维化/肝硬化与间充质干细胞:从发病机制到治疗
- Author:
Zhu-yuan SI
1
;
Sai ZHANG
;
Zhong-yang SHEN
Author Information
1. 山东大学齐鲁医院 器官移植科(山东 济南 250012);天津市第一中心医院 器官移植中心(天津 300190)
- Publication Type:Journal Article
- Keywords:
Liver fibrosis;
Cirrhosis;
Mesenchymal stem cell;
Pathogenesis;
Treatment
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(12):925-931
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis/cirrhosis is an abnormal proliferative disease of connective tissue in the liver caused by multiple etiologies,with a complex pathogenesis and challenging treatment.Endogenous mesenchymal stem cell(MSC)plays a crucial role in the pathogenesis of liver fibrosis;Clinical trials have shown that exogenous MSC can be used for the treatment of liver cirrhosis.This article summarizes the controversies surrounding the pathogenesis and treatment of MSC in liver fibrosis/cirrhosis,and explores the clinical application of MSC in liver cirrhosis.
