Advance in lipid metabolism disorder and vascular aging
10.20039/j.cnki.1007-3949.2025.06.011
- VernacularTitle:脂代谢紊乱与血管衰老研究进展
- Author:
Yun WANG
1
;
Huijuan LI
1
;
Xiaping JIANG
1
;
Yuncheng LÜ
1
Author Information
1. 桂林医科大学基础医学院广西糖尿病系统医学重点实验室 基础医学研究所,广西壮族自治区 桂林市 541199
- Publication Type:Journal Article
- Keywords:
lipid metabolism disorder;
vascular aging;
oxidative stress;
inflammation
- From:
Chinese Journal of Arteriosclerosis
2025;33(6):539-545
- CountryChina
- Language:Chinese
-
Abstract:
To analyse the role and mechanism of lipid metabolism disorder in vascular aging caused by endothelial cells,smooth muscle cells,and macrophages.Lipid metabolism disorder damages endothelial cells and promotes vascular aging through the reactive oxygen species(ROS)pathway,endothelial nitric oxide synthase(eNOS)activity,oxidized low density lipoprotein(ox-LDL),inflammasomes,and various inflammatory factors.Lipid metabolism disorder accelerates vascular aging process through autophagy,DNA damage,and nuclear factor-κB(NF-κB)in vascular smooth muscle cells.Lipid metabolism disorder stimulates macrophages in the vascular wall to secrete various inflammatory factors that act on the Toll-like receptor(TLR)pathway,promoting oxidative stress and causing DNA damage,thereby promoting vascular aging.Lipid metabolism disorder promotes oxidative stress and chronic inflammation in endothelial cells,smooth muscle cells,and macrophages,leading to vascular aging.
