Sepsis treatment for 20 years: a breakthrough is still to be made

VernacularTitle:脓毒症治疗20年：砥砺前行，仍待突破
Author: Xiaoxiao LI ¹ ; Shuo WANG ; Chunsheng LI
Author Information

1. 首都医科大学附属北京中医医院感染性疾病科（发热门诊），北京　100010
Publication Type:Journal Article
Keywords: Sepsis; Shock, septic; Systemic inflammatory response syndrome
From: Journal of Chinese Physician 2025;27(2):161-165
CountryChina
Language:Chinese
Abstract: Sepsis, as a serious systemic disease caused by infection, has always been hanging in the medical field like the " sword of Damocles", and has launched a continuous challenge to the global medical community with a high fatality rate and complex illness. The progression of sepsis into septic shock will increase the mortality of patients. Therefore, early identification and standardized treatment of sepsis are extremely important. In the past 20 years, the definition and diagnostic criteria of sepsis have been updated several times, striving to improve the clinical identification and screening ability of sepsis, emphasizing the importance of highlighting organ dysfunction in sepsis patients, aiming to break the dilemma of high mortality, improve patient prognosis, and improve quality of life. This paper reviews the evolution and research progress of sepsis in the past 20 years in terms of definition, diagnostic criteria, etiology, pathogenesis and treatment.