Research progress on idebenone in cognitive impairment of parkinson′s disease
10.3760/cma.j.cn431274-20240115-00105
- VernacularTitle:艾地苯醌治疗帕金森病认知障碍的研究进展
- Author:
Yanhong REN
1
;
Xiaoran ZHU
1
;
Xiuhua LI
1
Author Information
1. 山东第一医科大学第一附属医院神经内科，济南 250014
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Cognition disorders;
Idebenone
- From:
Journal of Chinese Physician
2025;27(1):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease is a common neurodegenerative disorder, and cognitive impairment is a frequent non-motor symptom of the disease. The pathogenesis of cognitive impairment in Parkinson′s disease remains unclear, and effective treatment methods are still under investigation. Idebenone exhibits multiple protective effects, including scavenging free radicals, antioxidative stress, mitochondrial protection, anti-inflammation, and enhancing autophagy. It has shown preliminary efficacy in treating cognitive impairment associated with Parkinson′s disease. This article explores the potential of idebenone in treating cognitive impairment in Parkinson′s disease by examining the underlying pathogenic mechanisms and the specific properties of idebenone, providing a reference for clinical practice.
