Predictive value of MR diffusion kurtosis imaging-derived quantitative parameters combined with serum BRCA1 level for postoperative recurrence and metastasis in breast cancer patients
10.16753/j.cnki.1008-2344.2025.04.013
- VernacularTitle:MR扩散峰度成像定量参数联合血清BRCA1水平检测对乳腺癌患者术后复发转移的预测价值
- Author:
Jingwen TIAN
1
;
Fang TIAN
1
;
Xiaobei MA
1
Author Information
1. 陆军第八十三集团军医院影像中心,河南 新乡 453000
- Publication Type:Journal Article
- Keywords:
magnetic resonance;
postoperative recurrence and metastasis;
diffusion kurtosis imaging of magnetic resonance;
breast cancer susceptibility gene 1;
combined detection;
predictive value
- From:
Journal of Shenyang Medical College
2025;27(4):408-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of MR diffusion kurtosis imaging(DKI)-derived quantitative parameters combined with serum breast cancer susceptibility gene 1(BRCA1)level for postoperative recurrence and metastasis in breast cancer patients.Methods:A total of 73 patients with breast cancer who were treated in our hospital from Mar 2023 to Jan 2024 were selected as the study group,and another 73 patients with benign breast nodules who were treated in the same period were selected as the control group.The quantitative parameters of MR DKI[mean diffusion rate(MD)and diffusion kurtosis(MK)]and serum BRCA1 level were compared between the two groups and among subgroups of the study group with different clinical pathological characteristics,and the correlation was further analyzed.According to the recurrence status within 6 months after surgery,the patients were divided into recurrence/metastasis group(n=24)and non-recurrence/metastasis group(n=49).The MD,MK and serum BRCA1 level were compared between the two groups,and the predictive value was analyzed using the receiver operating characteristic(ROC)curve.Results:MD,MK,and serum BRCA1 level in the study group were higher than those in the control group(P＜0.05).Significant differences in MD,MK,and BRCA1 levels were observed among patients with different differentiation grades,clinical stages,and lymph node metastasis(P＜0.05).MD,MK,and serum BRCA1 level were positively correlated with clinical stage and lymph node metastasis,and negatively correlated with differentiation grades(P＜0.05).The recurrence/metastasis group exhibited higher MD,MK,and BRCA1 levels than the non-recurrence/metastasis group(P＜0.05).The area under the curve of the combined detection of MD,MK,and serum BRCA1 level for the recurrence of breast cancer patients was 0.856,with sensitivity of 91.67%and specificity of 79.59%.Conclusions:The quantitative parameters of MR DKI and serum BRCA1 level are closely related to clinical stages,differentiation degree,lymph node metastasis,and postoperative recurrence and metastasis,demonstrating significant value in early diagnosis,treatment,and prognosis of breast cancer.
