Prognostic value of serum NT-proBNP and cardiac ultrasound parameters in patients with hypertrophic cardiomyopathy complicated with pulmonary hypertension
10.3760/cma.j.cn431274-20231211-00662
- VernacularTitle:血清NT-proBNP与心脏超声参数对肥厚型心肌病患者合并肺动脉高压的预测价值
- Author:
Jie FANG
1
;
Na LI
Author Information
1. 中国人民解放军联勤保障部队第九六〇医院心血管内科，济南 250031
- Publication Type:Journal Article
- Keywords:
Echocardiography;
N-terminal pro-B-type natriuretic peptide;
Hypertrophic cardiomyopathy;
Pulmonary arterial hypertension
- From:
Journal of Chinese Physician
2025;27(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of serum N-terminal B-type natriuretic peptide precursor (NT-proBNP) and cardiac ultrasound parameters in patients with hypertrophic cardiomyopathy (HCM) complicated with pulmonary hypertension (PAH).Methods:A total of 280 patients with HCM admitted to the 960th Hospital of the Joint Logistics Support Force of Chinese People′s Liberation Army from September 2020 to September 2023 were selected as the study objects. Patients with PAH were set as the observation group ( n=116), and patients without PAH were set as the control group ( n=164). General data of the two groups of patients were collected, and the serum indexes [cardiac troponin I (cTnI), cardiac troponin T (cTnT), NT-proBNP, cardiac fatty acid binding protein (H-FABP)] and cardiac ultrasound indexes [left and right atrial diameter, left ventricular posterior wall thickness, left ventricular ejection fraction (LVEF) were measured. Pulmonary artery diameter (PAD), mitral valve E/e′ value, etc.]. Multivariate logistic regression analysis was used to study the factors affecting the occurrence of PAH in HCM patients, and a model for predicting PAH was developed based on these factors. The validity of the diagnostic model was evaluated by receiver operating characteristic (ROC) curve. Results:Serum NT-proBNP, left atrial diameter, right atrial diameter, left ventricular posterior wall thickness, PAD and pulmonary artery systolic pressure (PASP) in the observation group were higher than those in the control group, while LVEF was lower than that in the control group, with statistical significance (all P<0.05). Multivariate logistic analysis showed that NT-proBNP, left atrial diameter, right atrial diameter, left ventricular posterior wall thickness, LVEF, PAD and PASP were all influencing factors of HCM with PAH (all P<0.05). The model constructed with this factor predicted that the area under ROC curve of HCM patients with PAH was 0.991. Conclusions:NT-proBNP, atrial inner diameter, left ventricular posterior wall thickness, LVEF, PAD and PASP are all influential factors of PAH in HCM patients, and have high predictive value for the diagnosis of PAH.
