Value of contrast-enhanced ultrasound parameters, SII and NLR levels in prognosis evaluation of prostate cancer after radical resection
10.3760/cma.j.cn431274-20231228-00747
- VernacularTitle:超声造影参数、SII及NLR水平对前列腺癌根治术预后评估的价值
- Author:
Yan ZHAO
1
;
Lei ZOU
;
Jingyu CHEN
;
Xingwei ZHOU
;
Tao ZHANG
Author Information
1. 安康市中医医院超声医学科，安康 725000
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Contrast-enhanced ultrasound;
Systematic immune-inflammation index;
Neutrophil;
Lymphocyte
- From:
Journal of Chinese Physician
2024;26(12):1830-1834
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of contrast-enhanced ultrasound parameters, systemic immune-inflammation index (SII) and neutrophil to lymphocyte ratio (NLR) in the prognosis of prostate cancer after radical resection.Methods:The clinical data of 94 patients with radical resection of prostate cancer admitted to the Ankang Hospital of Traditional Chinese Medicine from February 2018 to February 2023 were retrospectively analyzed. The patients were followed up for 2 years after surgery. According to the follow-up results, the patients were divided into a recurrence group (37 cases) and a non-recurrence group (57 cases). Basic data [including age, body mass index (BMI), diabetes, hypertension, clinical stage, course of disease, Gleason score, surgical method, and American Society of Anesthesiologists (ASA) grade], preoperative SII and NLR, and postoperative 1 d contrast-enhanced ultrasound data of the two groups were collected, and compared between groups. The risk factors of postoperative recurrence in patients with prostate cancer were screened by unconditional logistic step-by-step regression analysis. The effectiveness of contrast ultrasound parameters, SII and NLR in evaluating postoperative recurrence of prostate cancer was analyzed by receiver operating characteristic (ROC) curve. At the same time, the prediction model of postoperative recurrence of prostate cancer patients was constructed and verified by ROC curve.Results:There were no significant differences in age, BMI, diabetes, hypertension, course of disease, surgical method and ASA classification between the two groups (all P>0.05). The proportion of clinical stage Ⅲ to Ⅳ, Gleason score, peak intensity (PI), mean time of passage (MTT), area under the curve (AUC), half time of intensity decline (HT), ascending branch slope (WIS), platelet count, SII and NLR in the non-recurrent group were lower than those in the recurrent group, and the differences were statistically significant (all P<0.05). Multivariate logistic regression analysis confirmed that clinical stage Ⅲ to Ⅳ, Gleason score, PI, MTT, AUC, HT, WIS, platelet count, SII and NLR were risk factors for postoperative recurrence of prostate cancer patients (all P<0.05). ROC curve analysis results showed that the areas under the curve of PI, MTT, AUC, HT, WIS, SII and NLR for postoperative recurrence of prostate cancer patients were 0.850, 0.923, 0.867, 0.856, 0.788, 0.746 and 0.932, respectively. The sensitivity was 0.811, 0.838, 0.784, 0.811, 0.703, 0.676, 0.892, respectively. According to the results of multivariate logistic regression analysis, the prediction model of postoperative recurrence of prostate cancer patients was fitted as Logit( P)=-3.661+ 0.464×clinical stage+ 0.611×Gleason score+ 0.617×PI+ 0.901×MTT+ 1.071×AUC+ 0.952×HT+ 0. 728×WIS+ 0.568×platelet count+ 0.628×SII+ 0.750×NLR. ROC curve results showed that the area under the curve of the model for predicting postoperative recurrence of prostate cancer patients was 0.953, standard error was 0.035, 95% CI was 0.884-1.000, sensitivity was 0.958, and specificity was 0.911. Conclusions:Contrast-enhanced ultrasound parameters, SII and NLR have certain value in the prognosis evaluation of prostate cancer after radical resection, and can be used as clinical indicators to evaluate whether the recurrence is possible.
