Advances in Research on the Mechanisms of FOXO in Renal Mitochondrial Autophagy
10.12290/xhyxzz.2024-0342
- VernacularTitle:FOXO在肾脏线粒体自噬中的作用机制研究进展
- Author:
Xiu DU
1
;
Minghai SHAO
1
;
Yanru WANG
1
;
Lin XU
1
Author Information
1. 上海中医药大学附属曙光医院,上海 201203
- Publication Type:Journal Article
- Keywords:
renal disease;
forkhead box O;
mitochondria;
mitochondrial autophagy;
oxidative stress
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(4):973-979
- CountryChina
- Language:Chinese
-
Abstract:
Forkhead box O(FOXO)transcription factors serve as critical signaling hubs,initiating downstream autophagy-related gene expression in response to various growth factors and participating in mito-chondrial autophagy,thereby influencing cellular damage and repairing processes in acute and chronic kidney diseases.This article reviews the regulatory mechanisms of FOXO transcription factors and their impacts on au-tophagy and mitochondrial autophagy,aiming to explore the prospects of FOXO-induced mitochondrial autophagy in the treatment of renal diseases.
