A Case with Abnormally Elevated INR Caused by the Combination of Astragalus Oral Liquid and Warfarin
10.3870/j.issn.1004-0781.2025.03.025
- VernacularTitle:黄芪精口服液联用华法林致国际标准化比值异常升高1例
- Author:
Yuan GAO
1
;
Yanping WANG
;
Boxia LI
Author Information
1. 兰州大学第一医院药剂科,兰州 730000;宁夏回族自治区人民医院(宁夏医科大学附属自治区人民医院)药学部,银川 750000
- Publication Type:Journal Article
- Keywords:
Warfarin;
Huangjing(astragalus)oral liquid;
Adverse drug reaction;
Drug-drug interaction
- From:
Herald of Medicine
2025;44(3):480-481
- CountryChina
- Language:Chinese
-
Abstract:
One patient who underwent mechanical aortic valve replacement was in good condition after surgery,and was discharged with warfarin(2.25 mg·d-1 and 3 mg·d-1 alternatively)and INR 1.91 under the guidance of the pharmacist.After discharge,in addition to taking warfarin and other medication for heart failure treatment,he purchased Huangjing(astragalus)o-ral liquid at the pharmacy and took it everyday.Twelve days later,he developed recurrent gingival bleeding and INR was 4.95.Warfarin and astragalus oral liquid were stopped immediately,and warfarin was restarted 3 days later.INR was monitored and the dose was adjusted.The maintenance dose of warfarin was 3 mg·d-1 and the INR was around 2.0.It was considered that the abnor-mally elevated INR was caused by the interaction between warfarin and astragalus extract oral solution.
